Promising #anti-cancer #virus–from #smallpox to #cancer
An engineered virus, injected into the blood, can selectively target cancer cells throughout the body. Researchers said the findings could one day "truly transform" therapies.
Cancer specialists said using viruses showed "real promise".
Using viruses to attack cancers is not a new concept, but they have needed to be injected directly into tumours in order to evade the immune system.
Smallpox to cancer
Scientists modified the vaccinia virus, which is more famous for being used to develop a smallpox vaccine.
The virus, named JX-594, is dependent upon a chemical pathway, common in some cancers, in order to replicate.
It was injected at different doses into the blood of 23 patients with cancers which had spread to multiple organs in the body.
In the eight patients receiving the highest dose, seven had the virus replicating in their tumours, but not in healthy tissue.
Prof John Bell, lead researcher and from the University of Ottawa, said: "We are very excited because this is the first time in medical history that a viral therapy has been shown to consistently and selectively replicate in cancer tissue after intravenous infusion in humans.
"Intravenous delivery is crucial for cancer treatment because it allows us to target tumours throughout the body as opposed to just those that we can directly inject."
Infection prevented further tumour growth in six patients for a time. However, the virus did not cure cancer. Patients were given only one dose of the virus as the trial was designed to test the safety of the virus.